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| Kibugu, J.K; Makumi, J.N; Ngeranwa, J.J.N; Kagira, J.M; Gathumbi, J.K; Mwangi, J.N. |
| Aflatoxins are known to alter the pathogenesis of many infectious diseases, but such effects have not been evaluated in trypanosome infections. The aim of the present work was to assess the effects of aflatoxin B1 on the pathogenesis of Trypanosoma brucei rhodesiense infection using a murine model. Mice fed on 0.50 mg/kg aflatoxin b. wt. were infected with T. b. rhodesiense and compared to trypanosome infected and uninfected aflatoxin-fed controls. The clinical and pathological changes were determined and the quantitative data statistically analysed using standard methods. The results showed that infected aflatoxin-fed mice had pronounced dyspnoea, significantly (P<0.05) reduced survival, extreme emaciation, pronounced macrocytic normochromic anaemia... |
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Palavras-chave: Aflatoxin B1; Trypanosomiasis; Pathogenesis; Mice. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2384 |
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| Ndungu, K; Kagira, J.M; Ngotho, J.M; Ouma, J; Bett, B; Gitonga, P. |
| Clinical and pathological characterisation of blood stream (BSF) and cerebrospinal fluid (CSF) forms of Trypanosoma brucei rhodesiense trypanosome isolated from a sleeping sickness patient were investigated in rabbits. The study aimed at investigating whether there is any significant difference in clinical and pathological presentation in rabbits infected by the two forms of trypanosomes. Each form of parasite was inoculated into five rabbits at 104 trypanosomes/ml while five rabbits were used as un-infected controls. Parasitaemia development, body temperature, packed cell volume (PCV), body weight, food and water intake, heartbeat and respiration were monitored daily for 30 days post infection when the experiment was terminated. Pathological changes were... |
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Palavras-chave: Pathogenicity; Rabbits; T. b. rhodesiense; CSF and Blood stream forms. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2387 |
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| Mbuthia, S.K; Wachira, N.W; Ngure, R.M; Ouma, J; Kagira, J.M. |
| The current study investigated the effects of different types of Kenyan tea extracts on the pathogenesis of Trypanosoma brucei brucei in a Swiss White mice model. Following infection with trypanosomes, the mice were monitored for survival and liver pathology. Tea significantly (P<0.05) enhanced the survival rate of tea treated mice. Additionally, in tea treated but infected mice, there was reduction in infiltration of inflammatory cells into the periportal and parenchymal regions as well as hepatocyte cell damage compared to the infected untreated animals. Green and white teas were superior in most of the above effects while black tea and oolong teas had the least effects. The tea extracts were more efficacious than dexamethasone in prolonging the life... |
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Palavras-chave: Inflammation; Liver pathology; Survival rate; Tea; Trypanosomiasis. |
| Ano: 2011 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3094 |
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